51255-17-5: Decitabine Impurity 1 (alpha-Isomer)

Decitabine Impurity 1 (alpha-Isomer) (CAS No.: 51255-17-5) or Methyl-2-deoxy-alpha-D-ribofuranoside is a major impurity identified in Decitabine. Decitabine blocks DNA methyltransferase and depicts therapeutic effects in patients having hematologic malignancies. It shows its activity through the induction of hypomethylation and reactivation of critical genes.

Additional information

Catalogue No.

VE008128

CAS No.

51255-17-5

Molecular Formula

C6H12O4

Molecular Weight

148.16 g/mol

IUPAC Name

(2R, 5R)-2-(Hydroxymethyl)-5-methoxyoxolan-3-ol

Synonyms

Methyl-2-deoxy-alpha-D-ribofuranoside

References

Liu, Mingtao, et al. “HPLC Method Development, Validation, and Impurity Characterization of a Potent Antitumor Nucleoside, T-DCyd (NSC 764276).” Journal of Pharmaceutical and Biomedical Analysis, vol. 131, Nov. 2016, pp. 429–35, https://doi.org/10.1016/j.jpba.2016.08.034.?Oki, Yasuhiro, et al. “Decitabine—Bedside to Bench.” Critical Reviews in Oncology/Hematology, vol. 61, no. 2, Feb. 2007, pp. 140–52, https://doi.org/10.1016/j.critrevonc.2006.07.010.?

Status

In-stock