51255-17-5: Decitabine Impurity 1 (alpha-Isomer)
Decitabine Impurity 1 (alpha-Isomer) (CAS No.: 51255-17-5) or Methyl-2-deoxy-alpha-D-ribofuranoside is a major impurity identified in Decitabine. Decitabine blocks DNA methyltransferase and depicts therapeutic effects in patients having hematologic malignancies. It shows its activity through the induction of hypomethylation and reactivation of critical genes.
Additional information on CAS 51255-17-5
VE008128
51255-17-5
C6H12O4
148.16 g/mol
Decitabine
(2R, 5R)-2-(Hydroxymethyl)-5-methoxyoxolan-3-ol
Methyl-2-deoxy-alpha-D-ribofuranoside
Liu, Mingtao, et al. “HPLC Method Development, Validation, and Impurity Characterization of a Potent Antitumor Nucleoside, T-DCyd (NSC 764276).” Journal of Pharmaceutical and Biomedical Analysis, vol. 131, Nov. 2016, pp. 429–35, https://doi.org/10.1016/j.jpba.2016.08.034.?Oki, Yasuhiro, et al. “Decitabine—Bedside to Bench.” Critical Reviews in Oncology/Hematology, vol. 61, no. 2, Feb. 2007, pp. 140–52, https://doi.org/10.1016/j.critrevonc.2006.07.010.?
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