1140891-02-6: Decitabine related Compound C

Decitabine Related Compound C (CAS No.: 1140891-02-6) or 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-a-D-erythro-pentofurano syl]-1,3,5-triazin-2(1H)-one is an impurity of Decitabine which is the most extensively used blocker of DNA methylation which helps demethylation which leads to a consecutive reactivation of epigenetically silenced tumor suppressor genes.

Additional information

Catalogue No.

VE006539

CAS No.

1140891-02-6

Molecular Formula

C22H18Cl2N4O6

Molecular Weight

505.31

IUPAC Name

4-Amino-1-[3, 5-bis-O-(4-chlorobenzoyl)-2-deoxy-α-D-erythro-pentofurano syl]-1, 3, 5-triazin-2(1H)-one

References

Liu, Mingtao, et al. “HPLC Method Development, Validation, and Impurity Characterization of a Potent Antitumor Nucleoside, T-DCyd (NSC 764276).” Journal of Pharmaceutical and Biomedical Analysis, vol. 131, Nov. 2016, pp. 429–35, https://doi.org/10.1016/j.jpba.2016.08.034.?Daskalakis, Michael, et al. “Decitabine.” Recent Results in Cancer Research, Oct. 2009, pp. 131–57, https://doi.org/10.1007/978-3-642-01222-8_10.?

Status

In-stock