90632-33-0: Dihydroxycyclophosphamide

Dihydroxycyclophosphamide (CAS No.: 90632-33-0) or 2-(Bis(2-hydroxyethyl)amino)-1,3,2-oxazaphosphinane 2-Oxide is a metabolite of Cyclophosphamide. Cyclophosphamide is evaluated in chemotherapy and is a part of the standard treatment of Cancer. It is activated to alkylating metabolites by cytochrome P-450.

Additional information on CAS 90632-33-0

Catalogue No.

VE006893

CAS No.

90632-33-0

Molecular Formula

C₇H₁₇N₂O₄P

Molecular Weight

224.19

Parent drug

Cyclophosphamide

IUPAC Name

2-(Bis(2-hydroxyethyl)amino)-1, 3, 2-oxazaphosphinane 2-Oxide

Synonyms

Didechlorodihydroxycyclophosphamide

References

"Gurtoo, H. L., et al. “Effects of the Induction of Hepatic Microsomal Metabolism on the Toxicity of Cyclophosphamide.” British Journal of Cancer, vol. 51, no. 1, Jan. 1985, pp. 67–75, https://doi.org/10.1038/bjc.1985.10.?Clarke, Lynn, and David J. Waxman. “Oxidative Metabolism of Cyclophosphamide: Identification of the Hepatic Monooxygenase Catalysts of Drug Activation.” Cancer Research, vol. 49, no. 9, American Association for Cancer Research, May 1989, pp. 2344–50, cancerres.aacrjournals.org/c

Status

In-stock