1973402-05-9: Dolutegravir Inhouse Impurity B

Dolutegravir Inhouse Impurity B (CAS No.: 1973402-05-9) is impurity E of Dolutegravir which is a second-generation HIV-1 integrase strand transfer blocker. Dolutegravir is now been studied for the treatment of HIV infection. Dolutegravir has been proven to block HIV replication in cells like peripheral blood mononuclear cells (PBMCs), MT-4 cells, and CIP4 cells contaminated by the PHIV lentiviral vector.

Additional information

Catalogue No.

VE008093

CAS No.

1973402-05-9

Molecular Formula

C20H19F2N3O5

Molecular Weight

419.38 g/mol

IUPAC Name

N-[(2, 4-Difluorophenyl)methyl]-1, 8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1, 8-dioxo-2H-pyrido[1, 2-a]pyrazine-7-carboxamide

References

Garrido, Carolina, et al. “Resistance Associated Mutations to Dolutegravir (S/GSK1349572) in HIV-Infected Patients – Impact of HIV Subtypes and Prior Raltegravir Experience.” Antiviral Research, vol. 90, no. 3, June 2011, pp. 164–67, https://doi.org/10.1016/j.antiviral.2011.03.178.?“S/GSK1349572, a New Integrase Inhibitor for the Treatment of HIV: Promises and Challenges.” Expert Opinion on Investigational Drugs, 2011, http://www.tandfonline.com/doi/abs/10.1517/13543784.2011.562189.?

Status

In-stock