1973402-05-9: Dolutegravir Inhouse Impurity B

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Dolutegravir Inhouse Impurity B (CAS No.: 1973402-05-9) is impurity E of Dolutegravir which is a second-generation HIV-1 integrase strand transfer blocker. Dolutegravir is now been studied for the treatment of HIV infection. Dolutegravir has been proven to block HIV replication in cells like peripheral blood mononuclear cells (PBMCs), MT-4 cells, and CIP4 cells contaminated by the PHIV lentiviral vector.

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Additional information on CAS 1973402-05-9

Catalogue No. VE008093
CAS No. 1973402-05-9
Molecular Formula C20H19F2N3O5
Molecular Weight 419.38 g/mol
Parent drug Dolutegravir
IUPAC Name N-[(2, 4-Difluorophenyl)methyl]-1, 8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1, 8-dioxo-2H-pyrido[1, 2-a]pyrazine-7-carboxamide
Synonyms N/A
References Garrido, Carolina, et al. “Resistance Associated Mutations to Dolutegravir (S/GSK1349572) in HIV-Infected Patients – Impact of HIV Subtypes and Prior Raltegravir Experience.” Antiviral Research, vol. 90, no. 3, June 2011, pp. 164–67, https://doi.org/10.1016/j.antiviral.2011.03.178.?“S/GSK1349572, a New Integrase Inhibitor for the Treatment of HIV: Promises and Challenges.” Expert Opinion on Investigational Drugs, 2011, http://www.tandfonline.com/doi/abs/10.1517/13543784.2011.562189.?
Status In-stock

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1973402-05-9: Dolutegravir Inhouse Impurity B

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