Dolutegravir (DTG), sold under the brand name Tivicay, is an antiretroviral medication that belongs to the class of integrase strand transfer inhibitors (INSTIs). It is commonly used in combination with other antiretroviral agents to manage and treat HIV/AIDS. Dolutegravir works by inhibiting the HIV integrase enzyme, which prevents the integration of viral DNA into the host cell genome, thereby halting viral replication.
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir Impurity H
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir
Parent: Dolutegravir / Dolutegravir Sodium
![Ethyl(4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate](https://veeprho.com/wp-content/uploads/2023/03/Ethyl-4R-12aS-7-hydroxy-4-methyl-6-8-dioxo-3-4-6-8-12-12a-hexahydro-2H-pyrido-1-2-4-5-pyrazino-2-1-b-1-3-oxazine-9-carboxylate.png "Ethyl(4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate")
Parent: Dolutegravir
![(4R,12aR)-7 ethoxy 4 methyl 6,8 dioxo 3,4,6,8,12,12? hexahydro 2H pyrido[1',2':4,5]pyrazino[2,1 b][1,3] oxazine 9 carboxylic acid](https://veeprho.com/wp-content/uploads/2023/06/4R-12aR-7-ethoxy-4-methyl-6-8-dioxo-3-4-6-8-12-12-hexahydro-2H-pyrido-1-2-4-5-pyrazino-2-1-b-1.png "(4R,12aR)-7 ethoxy 4 methyl 6,8 dioxo 3,4,6,8,12,12? hexahydro 2H pyrido[1',2':4,5]pyrazino[2,1 b][1,3] oxazine 9 carboxylic acid")
Parent: Dolutegravir
![(4R,12aS)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid](https://veeprho.com/wp-content/uploads/2023/03/4R-12aS-7-ethoxy-4-methyl-6-8-dioxo-3-4-6-8-12-12a-hexahydro-2H-pyrido-1-2-4-5-pyrazino-2-1-b-1-3-oxazine-9-carboxylic-acid.png "(4R,12aS)-7-ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid")
Parent: Dolutegravir
Parent: Dolutegravir
Advanced analytical techniques like High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) are utilized to detect and quantify impurities in dolutegravir.
Avoid taking dolutegravir with antacids or supplements containing magnesium, aluminum, or calcium within two hours of administration, as these can reduce the absorption of the medication. Additionally, avoid excessive alcohol consumption, as it can increase the risk of liver side effects.
The main disadvantages include potential side effects like insomnia, headache, and gastrointestinal disturbances. Rarely, it can cause mood changes or allergic reactions. It may also pose risks for neural tube defects when used during early pregnancy.
Dolutegravir carries a low risk of liver toxicity and hypersensitivity reactions. In rare cases, it may lead to severe skin reactions or exacerbate preexisting mental health conditions.
Dolutegravir has a half-life of approximately 14 hours, meaning it can stay in the body for about 2–3 days after the last dose, depending on individual metabolism and kidney function.
