Edoxaban Impurity 10
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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

1255529-25-9Edoxaban Impurity 10

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Catalogue No.:VE008121
CAS No.:1255529-25-9
Mol. Formula:C24H30ClN7O4S
Mol. Weight:548.06 g/mol

Additional information on CAS 1255529-25-9

Parent drug

Edoxaban

IUPAC Name

N1-(5-chloropyridin-2-yl)-N2-((1R, 2S, 4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4, 5, 6, 7-tetrahydrothiazolo[5, 4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide

Pharmacopoeial Synonyms

N/A

Other Synonyms

Edoxaban (RSS)-Isomer

Smiles

O=C(NC1=NC=C(Cl)C=C1)C(N[C@H]2[C@@H](NC(C(S3)=NC4=C3CN(C)CC4)=O)C[C@@H](C(N(C)C)=O)CC2)=O

InChI

InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15+,17-/m0/s1

Description

The Edoxaban Impurity 10 is a well-characterized reference material that meets stringent regulatory standards set by USP, EMA, JP, and BP. It plays a key role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Edoxaban. Edoxaban Impurity 10 or Edoxaban (RSS)-Isomer (CAS No.1255529-25-9) or N1-(5-chloropyridin-2-yl)-N2-((1R,2S,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide. Factor Xa of coagulation cascade is a attractive target for anticoagulant treatment. Edoxaban is a oral direct factor Xa inhibitor.

References

“Noor, Jesmin I., et al. “Edaravone Inhibits Lipid Peroxidation in Neonatal Hypoxic-Ischemic Rats: An in Vivo Microdialysis Study.” Neuroscience Letters, vol. 414, no. 1, Feb. 2007, pp. 5–9, https://doi.org/10.1016/j.neulet.2006.10.024. ?”

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