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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

Eltrombopag Impurity 21

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Catalogue No.:	VE0014750
CAS No.:	N/A
Mol. Formula:	C27H27N5O4
Mol. Weight:	485.54 g/mol

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Additional information on Eltrombopag Impurity 21

Parent drug

Eltrombopag

IUPAC Name

(Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2′-hydroxy-N-(2-hydroxyethyl)-[1,1′-biphenyl]-3-carboxamide

Synonyms

N/A

Description

Eltrombopag Impurity 21 is a related substance of the small-molecule thrombopoietin receptor agonist eltrombopag, consistent with a structurally defined synthetic byproduct or process-related impurity rather than a simple degradation fragment. With molecular formula C27H27N5O4 and molecular weight 485.54 g/mol, it retains the heteroaromatic and carboxylate-rich scaffold characteristic of the parent API. Its occurrence is typically assessed under impurity-control frameworks aligned with ICH Q3A/Q3B, with definitive characterization requiring LC-MS/MS, high-resolution mass spectrometry, and orthogonal HPLC methods, often supported by NMR for structural assignment. No specific genotoxic alert is inherent from the name alone, but toxicological qualification depends on the impurity profile and route of formation.