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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

1798008-25-9Ezetimibe O-Fluorobenzene isomer

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Catalogue No.:	VL203005
CAS No.:	1798008-25-9
Mol. Formula:	C₂₄H₂₁F₂NO₃
Mol. Weight:	409.43 g/mol

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Additional information on CAS 1798008-25-9

Parent drug

Ezetimibe

IUPAC Name

(3R, 4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;

Pharmacopoeial Synonyms

N/A

Other Synonyms

Ezetimibe Fluoro Isomer

Smile

O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=CC=C4F)O

InChI

InChI=1S/C24H21F2NO3/c25-16-7-9-17(10-8-16)27-23(15-5-11-18(28)12-6-15)20(24(27)30)13-14-22(29)19-3-1-2-4-21(19)26/h1-12,20,22-23,28-29H,13-14H2/t20-,22+,23-/m1/s1

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

Ezetimibe O-Fluorobenzene Isomer, also known as Ezetimibe Fluoro Isomer is a highly characterized reference material. It fully complies with stringent regulatory standards, including those set by USP, EMA, JP, and BP. This product is essential for use in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Ezetimibe. Moreover, it comes with a detailed Structure Elucidation Report (SER), ensuring its accuracy and reliability for a wide range of analytical applications. Ezetimibe O-Fluorobenzene isomer (CAS No: 1798008-25-9) is an impurity of Ezetimibe that is used to reduce the amount of cholesterol and other fatty substances in the blood. It is a lipid-lowering compound that selectively suppresses the intestinal absorption of cholesterol and associated phytosterol.

References

Balasubramanian, Hariram, et al. Development of a Simple, Highly Selective RP-LC Method for the Quantification of Diastereomers and Other Related Substances of Ezetimibe Using Multivariate Analysis.” Journal of Chromatographic Science, Aug. 2018, https://doi.org/10.1093/chromsci/bmy084.