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167105-80-8Ketorolac EP Impurity E

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Catalogue No.:	VL237002
CAS No.:	167105-80-8
Mol. Formula:	C19H22N2O5
Mol. Weight:	358.39g/mol

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Additional information on CAS 167105-80-8

Parent drug

Ketorolac

IUPAC Name

(1RS)-5-Benzoyl-N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-2,3-dihydro-1H-pyrrolizine-1-carboxamide

Pharmacopeial Synonyms

Ketorolac Related Compound A

Synonyms

Ketorolac Tris Amide Impurity

Smiles

C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)NC(CO)(CO)CO

InChI

InChI=1S/C19H22N2O5/c22-10-19(11-23,12-24)20-18(26)14-8-9-21-15(14)6-7-16(21)17(25)13-4-2-1-3-5-13/h1-7,14,22-24H,8-12H2,(H,20,26)

Description

Ketorolac EP Impurity E, also designated Ketorolac Related Compound A and Ketorolac Tris Amide Impurity, is a structurally defined process-related impurity of the pyrrolizine carboxylic acid analgesic ketorolac. The substance, CAS 167105-80-8, has molecular formula C19H22N2O5 and molecular weight 358.39 g/mol. Its amide-rich architecture indicates formation during synthetic diversion, acyl-transfer side reactions, or incomplete cyclization control rather than simple oxidative degradation. Structural assignment and trace-level quantification typically require LC-MS/MS, LC-HRMS, and orthogonal HPLC-UV or NMR confirmation. Because it is a non-volatile polar impurity, GC-MS is generally of limited utility unless derivatization is applied.