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120568-11-8Losartan EP Impurity E

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Catalogue No.:	VL214012
CAS No.:	120568-11-8
Mol. Formula:	C14H12N4
Mol. Weight:	236.27 g/mol

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Additional information on CAS 120568-11-8

Parent drug

Losartan /Candesartan / Irbesartan

IUPAC Name

5-(4′-methylbiphenyl-2-yl)-1H-tetrazole

Pharmacopeial Synonyms

N/A

Synonyms

Irbesartan Methyl Impurity; Candesartan Methyl Impurity; Losartan Methyl Impurity; 5-[2-(4-methylphenyl)phenyl]-2H-tetrazole; 5-[2-(4-Methylbiphenyl)]tetrazole ; 5-(4′-Methyl-(1,1′-biphenyl)-2-yl)-1H-tetrazole

Smiles

CC1=CC=C(C2=CC=CC=C2C3=NN=NN3)C=C1

InChI

InChI=1S/C14H12N4/c1-10-6-8-11(9-7-10)12-4-2-3-5-13(12)14-15-17-18-16-14/h2-9H,1H3,(H,15,16,17,18)

Description

Losartan EP Impurity E, CAS 120568-11-8, is the methyl-substituted biphenyl tetrazole derivative 5-[2-(4-methylphenyl)phenyl]-2H-tetrazole, also referred to as the Losartan, Irbesartan, or Candesartan methyl impurity. With formula C14H12N4 and molecular weight 236.27 g/mol, it represents a process-related structural analogue within the biaryl tetrazole class used in angiotensin II receptor antagonists. The impurity may arise from incomplete aryl coupling, methylated starting materials, or related synthetic side products. Determination typically relies on LC-MS/MS, LC-HRMS, and orthogonal HPLC-UV methods because of its aromatic nonpolar character and close chromatographic similarity to active pharmaceutical intermediates.