984-47-4: Medroxyprogesterone EP Impurity A

Status: In-stock

It is one of impurity present in Medroxyprogesterone, Medroxyprogesterone acetate inhibits the production of gonadotropin, preventing follicular maturation and ovulation, which is responsible for its ability to prevent pregnancy. This action also thins the endometrium. MPA reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium, also induces p53 dependant apoptosis in certain cancer cell lines, and inhibits GABA-A receptors, which reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium and induces p53 dependant apoptosis in cancer cell lines, Medroxyprogesterone Acetate used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding.

Additional information on CAS 984-47-4

Catalogue No. VE007815
CAS No. 984-47-4
Molecular Formula C24H34O5
Molecular Weight 402.54 g/mol
Parent drug Medroxyprogesterone
IUPAC Name (6R, 8R, 9S, 10R, 13S, 14S, 17R)-17-acetyl-6-hydroxy-6, 10, 13-trimethyl-3-oxo-2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
Synonyms N/A
References Piccinni, M.-P., Lombardelli, L., Logiodice, F., Kullolli, O., Maggi, E., & Barkley, M. S. (2019). Medroxyprogesterone Acetate Decreases Th1, Th17, and Increases Th22 Responses via AHR Signaling Which Could Affect Susceptibility to Infections and Inflammatory Disease. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.00642
Status In-stock

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984-47-4: Medroxyprogesterone EP Impurity A

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