It is one of impurity present in Milrinone, Milrinone is a partial competitive inhibitor of phosphodiesterase III, Milrinone increases intracellular cAMP responsible for its pharmacological effects including positive inotropy, positive lusitropy, and vasodilation. As milrinone affects cAMP levels through PDE-III and not through β-adrenergic receptors, it is effective in downregulated or otherwise desensitized β-adrenergic receptors and can be administered together with β-antagonists.
References
Ayres, J. K., & Maani, C. V. (2022, September 6). Milrinone. Retrieved November 4, 2022, from Nih.gov website: https://www.ncbi.nlm.nih.gov/books/NBK532943/
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