937275-23-5: Montelukast Methylketone Impurity
Montelukast Methylketone Impurity (CAS No: 937275-23-5) or Montelukast USP Related Compound E is an impurity present in montelukast which is approved as a treatment for intermittent and persistent allergic rhinitis (AR), can induce bronchoconstriction, increase microvascular permeability.
Additional information on CAS 937275-23-5
VL510002
937275-23-5
C₃₄H₃₂ClNO₃S
570.14
Montelukast
[1-[[[(1R)-3-(2-acetylphenyl)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid
1-[[[(1R)-3-(2-Acetylphenyl)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic Acid; Montelukast EP Impurity F; Montelukast USP Related Compound E; Montelukast Methylketone
CC(=O)C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O
Emerce, Esra, et al. “Determination of the Impurities in Drug Products Containing Montelukast and in Silico/in Vitro Genotoxicological Assessments of Sulfoxide Impurity.” Toxicology Letters, vol. 238, no. 2, Oct. 2015, pp. 90–99, https://doi.org/10.1016/j.toxlet.2015.07.003. ? Wang, D. “Simultaneous Determination of Montelukast Sodium S-Enantiomer and A5 Enantiomers in Montelukast Sodium Bulk Drug by Normal-Ph
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