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N-Nitroso N-desmethyl Pheniramine
● In Stock
| Catalogue No.: | VE0014203 |
|---|---|
| CAS No.: | N/A |
| Mol. Formula: | C15H17N3O |
| Mol. Weight: | 255.31 g/mol |
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Additional information on N-Nitroso N-desmethyl Pheniramine
Parent drug
PheniramineIUPAC Name
N-methyl-N-(3-phenyl-3-(pyridin-2-yl)propyl)nitrous amidePharmacopeial Synonyms
N/ASynonyms
N/ASmiles
CN(CCC(c1ccccc1)c2ccccn2)N=OInChI
InChI=1S/C15H17N3O/c1-18(17-19)12-10-14(13-7-3-2-4-8-13)15-9-5-6-11-16-15/h2-9,11,14H,10,12H2,1H3FDA Potency Category 1 NDSRI
26.5 ng/day is the U.S. FDA’s current Acceptable Intake (AI) limit for N-nitroso-desmethyl-pheniramine (NDSRI). Refer to the FDA nitrosamine page for the latest guidance.Description
N-Nitroso N-desmethyl Pheniramine is a nitrosamine impurity related to the pheniramine scaffold, arising plausibly from nitrosative conversion of the corresponding secondary amine during manufacture or storage under nitrite-containing conditions. With molecular formula C15H17N3O and molecular weight 255.31 g/mol, it presents structural features associated with class concern for mutagenic and potentially carcinogenic risk, warranting assessment under ICH M7 principles and nitrosamine-specific regulatory expectations. Trace-level determination generally requires orthogonal, high-sensitivity methods such as LC-MS/MS and, where volatility permits, GC-MS, often with selective ion monitoring or tandem fragmentation to resolve it from matrix interferences.Request a Quote
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