Stock Locations

New Jersey, USA
Czech Republic, EU
Mumbai, India

* Stock subject to availability.

Documentation

Download MSDS

Download Sample COA

Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

38536-28-6Nicergoline EP Impurity A

● In Stock

Catalogue No.:	VL1610001
CAS No.:	38536-28-6
Mol. Formula:	C24H26ClN3O3
Mol. Weight:	439.93 g/mol

Request a quote

Add to RFQ list

Additional information on CAS 38536-28-6

Parent drug

Nicergoline

IUPAC Name

[(6aR, 9R, 10aS)-10a-Methoxy-4, 7-dimethyl-4, 6, 6a, 7, 8, 9, 10, 10a-octahydroindolo[4, 3-fg]quinolin-9-yl]methyl 5-Chloropyridine-3-carboxylate

Pharmacopoeial Synonyms

Chloronicergoline

Other Synonyms

Debromo Chloro Nicergoline

Smile

O=C(C1=CC(Cl)=CN=C1)OC[C@H](C[C@]23OC)CN(C)[C@]3([H])CC4=CN(C)C5=C4C2=CC=C5

InChI

InChI=1S/C24H26ClN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

Description

Nicergoline EP Impurity A, also known as chloronicergoline, is a chlorinated ergoline-derived process impurity associated with nicergoline manufacturing or transformation chemistry. The compound, CAS 38536-28-6, has molecular formula C24H26ClN3O3 and molecular weight 439.93 g/mol. Its structural relationship to the parent alkaloid indicates formation through halogenated intermediate carryover or regioselective substitution during synthesis rather than simple hydrolysis. Owing to its defined structural signature and low-level occurrence, characterization commonly requires LC-MS/MS, high-resolution LC-MS, and orthogonal HPLC-UV methods, with impurity profiling aligned to pharmacopeial and ICH M7 risk assessment principles.

References

SHINTOMI, KEIICHI, et al. â€œPharmacological Effects of Nicergoline and Its Metabolites, Decomposition Products and Impurities in Animals.â€ Journal of Pharmacobio-Dynamics, vol. 10, no. 1, 1987, pp. 35â€“48, https://doi.org/10.1248/bpb1978.10.35.?Sortino, Maria Angela, et al. â€œNeuroprotective Effects of Nicergoline in Immortalized Neurons.â€ European Journal of Pharmacology, vol. 368, no. 2-3, Mar. 1999, pp. 285â€“90, https://doi.org/10.1016/s0014-2999(99)00041-2.?