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2213409-62-0Osimertinib 2-Amide Impurity
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| Catalogue No.: | VE0022389 |
|---|---|
| CAS No.: | 2213409-62-0 |
| Mol. Formula: | C23H20FN5O2 |
| Mol. Weight: | 417.44 g/mol |
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Additional information on CAS 2213409-62-0
Parent drug
OsimertinibIUPAC Name
N-(2-fluoro-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamidePharmacopoeial Synonyms
N/AOther Synonyms
2-Des(dimethylamino)ethyl]methylamino-2-Fluoro OsimertinibSmiles
CN(C1=C2C=CC=C1)C=C2C3=NC(NC4=C(OC)C=C(F)C(NC(C=C)=O)=C4)=NC=C3InChI
InChI=1S/C23H20FN5O2/c1-4-22(30)26-18-12-19(21(31-3)11-16(18)24)28-23-25-10-9-17(27-23)15-13-29(2)20-8-6-5-7-14(15)20/h4-13H, 1H2, 2-3H3, (H, 26, 30)(H, 25, 27, 28)Description
Osimertinib 2-Amide Impurity, also designated N-(2-fluoro-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide, is an amide and acrylamide-related process impurity associated with the osimertinib scaffold. The substance, CAS 2213409-62-0, has molecular formula C23H20FN5O2 and molecular weight 417.44 g/mol. Its occurrence is typically attributed to incomplete amidation, hydrolytic or transamidation events, or side reactions during late-stage synthesis. Because the acrylamide motif can warrant toxicological scrutiny, trace-level monitoring is commonly addressed under ICH M7 principles using LC-MS/MS or high-resolution LC-MS, with orthogonal confirmation by HPLC-UV and, where needed, NMR characterization.Request a Quote
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