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766480-48-2Sacubitril (2R,4R)-Isomer
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| Catalogue No.: | VE005968 |
|---|---|
| CAS No.: | 766480-48-2 |
| Mol. Formula: | C24H29NO5 |
| Mol. Weight: | 411.49 g/mol |
Additional information on CAS 766480-48-2
Parent drug
SacubitrilIUPAC Name
(2R, 4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl esterPharmacopoeial Synonyms
N/AOther synonyms
Sacubitril 4-EpimerSmiles
O=C(CCC(O)=O)N[C@H](C[C@H](C(OCC)=O)C)CC1=CC=C(C2=CC=CC=C2)C=C1InChl
InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21-/m1/s1Description
Sacubitril (2R,4R)-Isomer is a well-characterized reference material that meets stringent regulatory standards set by USP, EMA, JP, and BP. It plays a key role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Sacubitril. It is a neprilysin inhibitor that helps to reduce the risk of cardiovascular death.
References
Kaplinsky, Edgardo. “Sacubitril/Valsartan in Heart Failure: Latest Evidence and Place in Therapy.†Therapeutic Advances in Chronic Disease, vol. 7, no. 6, Oct. 2016, pp. 278–90, https://doi.org/10.1177/2040622316665350. ?Request a Quote
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