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Tadalafil N-Oxide
● In Stock
| Catalogue No.: | VL300005 |
|---|---|
| CAS No.: | N/A |
| Mol. Formula: | C22H18N3O5 |
| Mol. Weight: | 404.40 g/mol |
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Additional information on Tadalafil N-Oxide
Parent drug
TadalafilIUPAC Name
6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-1,4-dioxo-1,2,3,4,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indol-7(6H)-olateSynonyms
N/ASmiles
CN6CC(=O)N1C(Cc4c(C1c3ccc2OCOc2c3)n(O)c5ccccc45)C6=ODescription
Tadalafil N-Oxide is the N-oxidized pyridine-related impurity of tadalafil, arising plausibly through oxidative transformation during synthesis, storage, or stress exposure. With molecular formula C22H18N3O5 and molecular weight 404.40 g/mol, it represents a polar heteroaromatic degradant that may alter chromatographic behavior relative to the parent phosphodiesterase 5 inhibitor. Its assignment and trace-level quantification typically require LC-MS/MS, high-resolution LC-MS, and orthogonal LC-UV methods, with attention to ionization-dependent response and isomeric separation. Although not a nitrosamine, its impurity status warrants regulatory assessment under impurity-control paradigms, including degradation profiling and structure elucidation by tandem mass spectrometry.Request a Quote
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