Also known as Atorvastatin Related Compound E or ent-Atorvastatin or (3S, 5S)-Atorvastatin (Na Salt), it is one of impurity present in Atorvastatin, Atorvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, which catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver, where decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low-density lipoprotein receptors, which increases the hepatic uptake of LDL. Atorvastatin also reduces Very-Low-Density Lipoprotein-Cholesterol, serum triglycerides, and Intermediate Density Lipoproteins, but increases High-Density Lipoprotein Cholesterol. which is used to treat myocardial infarction and stroke.
References
McIver, L. A., & Siddique, M. S. (2022, September 2). Atorvastatin. Retrieved October 31, 2022, from Nih.gov website: https://www.ncbi.nlm.nih.gov/books/NBK430779/
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