2-Amino-9-(((2-hydroxyethoxy)methoxy)methyl)-1,9-dihydro-6H-purin-6-one compound with 2-amino-9-((2-(hydroxymethoxy)ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (1:1)
同義語
N/A
説明
Acyclovir EP Impurity Q は、分子式 C18H26N10O8、分子量 510.46 を有する、構造関連性の高いヌクレオシド不純物である。その組成は高度に官能基化されたグアニン由来アナログを示唆し、単純な工程残留物よりも、酸化体または過アシル化副生成物として理解するのが妥当である。この種の化合物は、アシクロビル製造における多段階の保護、グリコシル化、最終脱保護工程で生じうる。近縁なプリン系不純物は含量定量の特異性と不純物プロファイルに影響し得るため、同定と定量には通常、逆相 LC と高分解能 MS の連結、MS/MS 断片解析、さらに微量分離のための LC-UV の補完が必要となる。
References
O’Brien, John J., and Deborah M. Campoli-Richards. “Acyclovir.†Drugs, vol. 37, no. 3, Mar. 1989, pp. 233–309, 10.2165/00003495-198937030-00002.
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