Also known as 3-Dehydroxy 2, 3-Dehydro Atorvastatin Lactone, Atorvastatin Dehydro Lactone, Atorvastatin Eliminated Lactone, it is highly protein-bound in serum to a-1-acid glycoprotein (AAG) and albumin, it is extensively metabolized in the liver, primarily by cytochrome (CYP450)3A isoenzymes – 3A4 and 3A5.
References
McIver, Lindsey A., and Momin S. Siddique. Atorvastatin.” Nih.gov, StatPearls Publishing, 5 Jan. 2019, www.ncbi.nlm.nih.gov/books/NBK430779/.
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