Atorvastatin Related Compound E は Atorvastatin EP Impurity E、Ent-Atorvastatin、Atorvastatin 3S,5S 異性体のカルシウム塩としても記載され、アトルバスタチンの立体化学的エナンチオマーであり、分解生成物や変異原性アラート構造ではない。CAS 1105067-88-6、分子式 C66H68CaF2N4O10、分子量 1155.34 g/mol。通常は不斉合成由来の立体反転または工程由来混入を示し、薬理活性を示す 3R,5R 配置体と明確に区別する必要がある。微量定量にはキラル LC、LC-MS/MS、高分解能 MS が一般的に必要で、異性体および塩関連種の分離が求められる。規制上は立体化学的純度と不純物プロファイリングが中心となる。
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