Metoprolol EP Impurity H (O-Desmethyl Metoprolol, Betaxolol Hydroxyethyl Analog), CAS 62572-94-5, is a structurally defined related impurity characterized by a 2-hydroxyethyl substitution on the phenoxy ring that increases polarity and modifies chromatographic properties compared with the parent substance. The free base 1-[4-(2-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol is readily identified and quantified using reversed-phase HPLC, LC-MS and proton NMR, exhibiting a distinct retention profile and diagnostic fragment ions. Monitoring this impurity supports impurity profiling, synthetic route assessment and stability evaluation where precise analytical standards and robust methods are required for regulatory control.
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![1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride](https://veeprho.com/wp-content/uploads/2022/07/1-5B4-5B2-Hydroxy-3-5B1-methylethylamino5Dpropoxy5Dphenyl5D-2-methoxyethanone-Hydrochloride.png "1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride")
