Metoprolol Related Compound C は Metoprolol EP Impurity C および Bisoprolol EP Impurity L とも呼ばれ、4-(2-hydroxy-3-(isopropylamino)propoxy)benzaldehyde hydrochloride、CAS 1956321-87-1 に相当する。分子式 C13H19NO3.HCl、分子量 237.30, 36.46 g/mol を有し、ベータアリールオキシプロパノールアミン系のアルデヒド性関連物質である。これは、β遮断薬中間体の合成過程における側鎖還元の不完全反応、または酸化的変換により生成し得る。微量定量には LC-MS/MS と HPLC の直交法が一般的で、同定および不純物プロファイリングには LC-HRMS が用いられる。
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