An artificial fluoroquinolone antibiotic is moxifloxacin. The medication was created by Bayer AG. Moxifloxacin inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which causes it to have bactericidal effects. Involved in the replication, transcription, and repair of bacterial DNA, DNA gyrase is a crucial enzyme. A crucial portion of the partitioning of the chromosomal DNA during bacterial cell division is known to be played by the enzyme topoisomerase IV. The antibacterial drug moxifloxacin works by attaching to an enzyme called DNA gyrase and preventing bacteria from unwinding one DNA double helix into two, which is necessary for DNA replication. Notably, the drug's affinity for bacterial DNA gyrase is 100 times greater than for mammalian DNA gyrase.
References
Tulkens, Paul M., et al. “Moxifloxacin Safety.†Drugs in R&D, vol. 12, no. 2, June 2012, pp. 71–100, https://doi.org/10.2165/11634300-000000000-00000. ‌
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