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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

159345-93-4Pravastatin Diol Lactone

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カタログ番号:	VE0026471
CAS番号:	159345-93-4
分子式:	C18H26O5
分子量:	322.4 g/mol

見積もり依頼

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に関する追加情報 CAS 159345-93-4

親薬物

Pravastatin

IUPAC名

(4R,6R)-6-[2-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one

Pharmacopeial Synonyms

N/A

同義語

N/A

SMILES

C[C@H]1C=CC2=C[C@H](C[C@@H]([C@@H]2[C@H]1CC[C@@H]3C[C@H](CC(=O)O3)O)O)O

InChI

InChI=1S/C18H26O5/c1-10-2-3-11-6-12(19)8-16(21)18(11)15(10)5-4-14-7-13(20)9-17(22)23-14/h2-3,6,10,12-16,18-21H,4-5,7-9H2,1H3/t10-,12+,13+,14+,15-,16-,18-/m0/s1

説明

Pravastatin Diol Lactone (CAS 159345-93-4) is a known lactonized impurity of pravastatin that arises via intramolecular esterification of the diol under acidic or thermal stress. It exhibits altered physicochemical properties relative to the parent acid including reduced polarity and modified solubility, and can compromise potency and stability profiles if not controlled. Analytical detection and quantification are routinely performed by HPLC with UV or MS detection, supported by LC-MS and NMR for structural confirmation. Control strategies follow ICH impurity guidelines and include optimized synthetic conditions, pH control, and targeted purification to minimize formation and ensure batch-to-batch consistency.