Lisinopril dihydrate is the hydrated form of lisinopril, a widely used angiotensin-converting enzyme (ACE) inhibitor. It is prescribed for:
∙ High blood pressure (hypertension)
∙ Heart failure
∙ Post-myocardial infarction (after a heart attack)
∙ Diabetic nephropathy (kidney protection in diabetes)
Lisinopril works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reduced blood pressure, and lower strain on the heart. The dihydrate form is used to enhance stability and solubility in pharmaceutical formulations.
It is typically administered orally, once daily, and is available under several brand names including Prinivil and Zestril.

Parent: Lisinopril
Parent: Lisinopril Dihydrate
Impurities in lisinopril dihydrate can originate from chemical synthesis, formulation, or degradation, and are regulated under ICH Q3A/B guidelines to ensure product safety and quality.
Process-Related Impurities
Degradation Impurities
Elemental Impurities
Analytical Techniques for Impurity Detection
Lisinopril dihydrate is used to:
Common side effects include: