Adrenaline Tartrate EP Impurity C는 Adrenalone hydrochloride로도 불리며, 2-(3,4-Dihydroxyphenyl)-2-oxoethylmethylammonium의 염산염이다. CAS 62-13-5, 분자식 C9H12ClNO3, 분자량 217.65 g/mol의 이 카보닐 함유 카테콜아민 유도체는 일반적으로 에피네프린 관련 중간체의 산화적 탈아미노화 또는 합성적 산화에서 기원한다. 카테콜 골격은 추가적인 산화환원 전환에 민감하며, 구조적으로 유사한 종과의 크로마토그래피 상 공용출을 보일 수 있다. 동정과 정량에는 고분해능 LC-MS/MS가 통상 필요하며, 보조적으로 HPLC 전기화학 검출 또는 다이오드 어레이 검출, 필요 시 MS 절편화 분석이 사용된다. 이는 니트로사민으로 분류되지 않지만, 아드레날린성 원료의 불순물 양상 및 안정성 평가에서 중요한 종이다.
References
Bodor, Nicholas, and Gary Visor. Pharmaceutical Research, vol. 01, no. 4, 1984, pp. 168–73, https://doi.org/10.1023/a:1016348624897.
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