암로디핀 만니톨 부가체는 디히드로피리딘계 칼슘채널 차단제인 암로디핀과 폴리올 만니톨에 관련된 정의된 공정 유래 불순물이다. 분자식 C26H37ClN2O10, 분자량 573.04 g/mol로, 제조 또는 저장 중 카르보닐 매개 또는 탈수 촉진 조건에서 공유결합성 부가체가 형성된 것으로 해석된다. 이는 단순 분해산물도 아니고 전형적인 유전독성 불순물도 아니지만, 제형 내 상호작용 화학을 시사할 수 있다. 확인 및 정량에는 일반적으로 LC-MS/MS가 필요하며, 추가로 LC-HRMS, 분리 시료가 확보되면 HPLC-UV 또는 NMR 같은 직교 기법이 활용된다.
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