Bupropion Related Compound F(CAS 857233-13-7)은 부프로피온의 합성 및 분해 영역과 연관된 염소 치환 방향족 불순물로, 반응 경로 특이적 부반응 또는 불완전한 전환에서 기원하는 산화된 아릴 케톤 단편으로 해석된다. 분자식 C9H9ClO2, 분자량 184.5 g/mol의 구조적으로 정의된 저농도 성분으로서, 불순물 프로파일링과 구조 규명에 중요하다. 근접한 공정 불순물과 매트릭스 간섭 때문에 검출 및 정량에는 고분해능 LC-MS/MS, GC-MS, 그리고 UV 또는 다이오드 어레이 검출을 갖춘 크로마토그래피 분리가 통상 요구된다. 이 물질은 약전 및 ICH 불순물 관리 원칙에 따라 평가되는 것이 적절하다.
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