N-(2,6-Dichlorophenyl)Formamide is a well-characterized reference material that meets stringent regulatory standards set by USP, EMA, JP, and BP. It plays a key role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Clonidine. It is a degradation by-product of Clonidine. Clonidine is an a-adrenergic agonist which is a potent compound that improves the condition in some children unresponsive to haloperidol. Clonidine presumably acts by creating a blockade in central noradrenergic function.
References
Cohen, D. J., et al. “CLONIDINE in TOURETTE’S SYNDROME.†The Lancet, vol. 314, no. 8142, Sept. 1979, pp. 551–53, https://doi.org/10.1016/s0140-6736(79)91614-3.
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