Diclofenac Alcohol; Diclofenac Related Compound B; 2-[(2, 6-Dichlorophenyl)amino]benzenemethanol; [2-[(2, 6-Dichlorophenyl)
설명
Diclofenac EP Impurity C는 Diclofenac Related Compound C 또는 Diclofenac Alcohol Analog로도 불리며, 디클로페낙의 환원성 알코올 유도체에 해당하는 벤지히드롤형 불순물이다. CAS 27204-57-5, 분자식 C13H11Cl2NO, 분자량 268.14 g/mol. 이 물질은 과환원 또는 카복실산 기능기와 관련된 합성 및 대사성 부경로에서 형성될 수 있다. 니트로사민은 아니지만, 구조적으로 관련된 공정 관련 불순물로서 불순물 규명 원칙에 따라 관리가 요구된다. 극미량 정량은 일반적으로 LC-MS/MS, LC-HRMS 및 직교 HPLC에 의존하며, UV 검출만으로는 확정적 동정이 충분하지 않은 경우가 많다.
References
Lu, Yuqing, et al. “PEI-Modified Core-Shell/Bead-like Amino Silica Enhanced Poly (Vinyl Alcohol)/Chitosan for Diclofenac Sodium Efficient Adsorption.†Carbohydrate Polymers, vol. 229, Feb. 2020, p. 115459, https://doi.org/10.1016/j.carbpol.2019.115459.?Tang, Wei. “The Metabolism of Diclofenac – Enzymology and Toxicology Perspectives.†Current Drug Metabolism, vol. 4, no. 4, Aug. 2003, pp. 319–29, https://doi.org/10.2174/1389200033489398.?
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