레플루노마이드 관련 화합물 C는 레플루노마이드 EP 불순물 C 및 레플루노마이드 메타 이성질체로도 불리며, 레플루노마이드의 합성 불순물 프로파일에 속하는 위치 이성질체이다. CAS 61643-23-0은 분자식 C12H9F3N2O2, 분자량 270.21 g/mol의 불소화 피리딘 아마이드 유도체를 지칭한다. 그 생성은 일반적으로 트리플루오로메틸 피리딘 골격 형성 중의 이성질체 혼입 또는 위치선택적 부생성물 형성에 기인한다. 활성물질과의 구조적 근접성 때문에 극미량 정량은 통상 LC-MS/MS를 필요로 하며, 필요한 경우 관련 이성질체와의 크로마토그래피 분리를 동반한 고분해능 LC-MS가 사용된다.
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