Paroxetine HCl EP Impurity A는 Paroxetine Related Compound B 및 desfluoro paroxetine hydrochloride로도 불리며, 파록세틴의 방향족 고리에서 para-플루오로 치환기가 결여된 구조 유사체이다. CAS 1322626-23-2 및 1394842-91-1에 해당하며, 분자식은 C19H22ClNO3, 분자량은 347.84 g/mol이다. 이 비휘발성 유기 불순물은 일반적으로 산화적 분해보다는 불완전한 불소화, 합성 부반응 생성물, 또는 제조 경로 기원의 불순물과 연관된다. 검출 및 정량에는 LC-MS/MS와 LC-UV의 직교 분석이 요구되며, 입체화학적 순도가 중요할 경우 키랄 LC가 적용된다. 평가는 약전 불순물 관리 체계 내에서 이루어진다.
References
Paroxetine-The Antidepressant from Hell? Probably Not, But Caution Required By Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams Container: Psychopharmacology bulletin Publisher: MedWorks Media Global Year: 2016 Volume: 46 Issue: 1 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044489/
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