H-Cys-Ser(Ac)-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide formation between Cys1 and Cys7)
Pharmacopeial Synonyms
N/A
동의어
N/A
설명
Ser-2(Ac)-Calcitonin은 칼시토닌 유래의 아세틸화 펩타이드 관련 불순물로, N-말단 세린 잔기의 위치 특이적 변형에 의해 형성되며 저분자 분해물이 아니라 공정 또는 분해 연관 변이체로 간주된다. 분자식 C147H242N44O49S2, 분자량 3473.93 g/mol을 가지며, 이황화 결합된 칼시토닌 골격과 대형 치료용 펩타이드에 특징적인 높은 물리화학적 복잡성을 유지한다. 구조 규명과 정량에는 일반적으로 고분해능 MS가 결합된 LC-MS/MS가 필요하며, 펩타이드 매핑과 유사체의 크로마토그래피 분리가 보조적으로 사용된다. 아세틸화는 수용체 결합, 안정성, 전하 이질성에 영향을 줄 수 있어 불순물 프로파일링에서 의미가 있다.
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