Trazodone BP Impurity A는 trazodone N1-oxide로 확인되며, CAS 55290-68-1에 해당하는 트라조돈의 N-옥사이드 대사체이자 공정 관련 분해산물이다. 3차 피페라진 질소의 산화로 형성되는 이 극성 헤테로방향족 N-옥사이드는 분자식 C19H22ClN5O2, 분자량 387.86 g/mol을 갖는다. 생성은 산화 스트레스, 저장 중 열화 또는 시료 취급 과정에서 발생할 수 있다. 극미량 정량에는 일반적으로 LC-MS/MS와 고분해능 MS 확인이 요구되며, 크로마토그래피 특성화에는 HPLC-UV, 불순물 동정에는 필요 시 LC-HRMS가 사용된다. 이는 니트로사민이 아니지만, ICH 체계에서 불순물 규명 및 분해 연구와 관련된 화학종이다.
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