트라조돈 BP 불순물 E, 즉 트라조돈 4-에틸 불순물은 트라조돈과 구조적으로 관련된 공정 유래 불순물로서 CAS 1346599-35-6에 해당한다. 분자식은 C21H26ClN5O, 분자량은 399.92 g/mol이며, 모체 골격의 특징인 트리아졸로피리디닐 및 클로로페닐 모티프를 유지하면서 에틸 치환 측쇄 변이를 가진다. 이러한 불순물은 일반적으로 불완전한 알킬화, 측쇄 재배열, 또는 합성 경로의 미세한 편차로 인해 형성된다. 검출과 구조 확인에는 보통 LC-MS/MS가 필요하며, 보조적으로 HPLC-UV와 필요 시 고분해능 MS가 사용되어 약전 및 ICH Q3A/Q3B 기준에 따른 불순물 프로파일링을 뒷받침한다.
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