Abietic Acid Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Abietic Acid Dehydroabietic Acid VL5000002View CAS 1740-19-8
Abietic Acid Dichlordehydroabietic Acid VL5000004View CAS 57055-39-7
Abietic Acid 12, 14-Dichlorodehydroabietic acid VE0010005View CAS 65281-77-8
Abietic Acid 14-Chlorodehydroabietic Acid VL5000003View CAS 65281-76-7

Abietic Acid Related Compound

Abietic acid is used to treat cardiovascular and cerebrovascular conditions, promote lipid metabolism, maintain human body fluids alkaline, and improve human body functioning.

References

  •          WANG, Jianguo. “WO2016019481 USES of ABIETIC ACID in MEDICAL TREATMENT.” Wipo.int, Feb. 2016, https://doi.org/WO2016019481.
  • Wikipedia Contributors. “Abietic Acid.” Wikipedia, Wikimedia Foundation, 27 Oct. 2022,en.wikipedia.org/wiki/Abietic_acid.
  • Liu, Xueping, et al. “Abietic Acid Suppresses Non-Small-Cell Lung Cancer Cell Growth via Blocking IKKβ/NF-ΚB Signaling.” OncoTargets and Therapy, vol. Volume 12, June 2019, pp. 4825–37, https://doi.org/10.2147/ott.s199161.
  •         PubChem. “Abietic Acid.” @Pubchem, PubChem, 2023, pubchem.ncbi.nlm.nih.gov/compound/Abietic-acid.

FAQ’s

What additional use does abietic acid have other than cardiovascular?

It is an organic molecule formed from four isoprene units that belongs to the abietane diterpene group. It’s utilised in lacquers, varnishes, and soaps, as well as resin analysis and the production of metal resinates.

Is abietic acid used in the treatment of lung cancer?

Abietic acid has anti-proliferative, cell cycle stopping, and pro-apoptotic properties. Mechanistically, abietic acid prevented tumour necrosis factor-induced activation of IB kinase (IKK/) (Ser176/180) and IkB (Ser32), as well as nuclear factorB translocation.

What medicine contains abietic acid?

Abietic acid is a naturally occurring substance discovered in Ceroplastes pseudoceriferus and Pinus brutia var.

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1740-19-8: Dehydroabietic Acid

1740-19-8: Dehydroabietic Acid
Catalogue No.

VL5000002

CAS No.

1740-19-8

Molecular Formula

C20H28O2

Molecular Weight

300.44

Parent drug

Abietic Acid

IUPAC Name

(1R, 4aS, 10aR)-1, 2, 3, 4, 4a, 9, 10, 10a-Octahydro-1, 4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic Acid

Synonyms

Abieta-8,11,13-trien-18-oic acid

References

Liu, Ming-Liang, et al. “The Synthesis and Antistaphylococcal Activity of Dehydroabietic Acid Derivatives: Modifications at C-12.” Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 22, Nov. 2016, pp. 5492–96, https://doi.org/10.1016/j.bmcl.2016.10.018.

Status

Under Development

ListName

Dehydroabietic Acid

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