Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It works by modulating dopamine and serotonin receptors in the brain, helping to stabilize mood, reduce psychosis, and manage acute manic or mixed episodes.
Mechanism of Action:
∙ Dopamine D₂ receptor antagonist (reduces psychotic symptoms)
∙ Serotonin 5-HT₂A receptor antagonist (enhances mood regulation)
∙ Partial agonist at 5-HT₁A receptors (may contribute to anxiolytic effects)
Ziprasidone is available in:
∙ Capsules for oral use
∙ Injectable form for acute agitation in schizophrenia
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
![5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloro-1-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)indolin-2-one](https://veeprho.com/wp-content/uploads/2022/09/5-2-4-benzo-d-isothiazol-3-yl-piperazin-1-yl-ethyl-6-chloro-1-2-6-chloro-2-oxoindolin-5-yl-ethyl-indolin-2-one.png "5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloro-1-(2-(6-chloro-2-oxoindolin-5-yl)ethyl)indolin-2-one")
Parent: Ziprasidone
Parent: Ziprasidone
Parent: Ziprasidone
Because ziprasidone is a complex heterocyclic compound, impurities can arise during synthesis, formulation, or storage. Regulatory standards like ICH Q3A/B ensure tight control over these impurities.
Process-Related Impurities
Degradation Impurities
Elemental Impurities
Analytical Techniques for Impurity Detection
Ziprasidone is used to treat:
QT interval prolongation (requires ECG monitoring in some patients)
