Etacrynic Acid EP Impurity A (CAS 1217-67-0) | também conhecida como Ethacrynic Acid Related Compound A ou (2 | 3-dichloro-4-butyrylphenoxy)acetic acid | é uma impureza clorada frequentemente detectada em lotes e matérias-primas do ácido etacrínico. Caracteriza-se por um anel fenílico diclorado ligado a um grupo butirol e a uma cadeia acética fenoxila | o que influencia polaridade e comportamento cromatográfico. A presença desta impureza compromete pureza | perfil de degradação e conformidade com limites farmacopéicos | exigindo quantificação por métodos validados como HPLC | LC-MS e RMN | além de estratégias de controle de processo e purificação para redução a níveis aceitáveis.
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