Impureza relacionada ao Candesartan cilexetil (CAS 145040-37-5) | identificada como subproduto estrutural com modificação no grupo éster 1-[[(ciclohexioxi)carbonil]oxi]etil | apresenta caracterização analítica robusta por HPLC | LC-MS e RMN; tipicamente detectada por tempo de retenção deslocado e massa molecular consistente com perda parcial ou rearranjo do éster | esta impureza exige quantificação por método cromatográfico validado e confirmação estrutural por espectrometria de massas e 1H/13C RMN. Solúvel em metanol e DMSO | mostra estabilidade limitada em solução aquosa e sensibilidade à hidrólise | pelo que se recomendam armazenamento em frio e procedimentos de controle de qualidade específicos para monitoramento e redução em lotes.
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