2′-S-Fluoro sofosbuvir é uma impureza estrutural relevante do processo de síntese do sofosbuvir | caracterizada pela substituição fluorada no carbono 2′ com configuração S. Esta impureza apresenta massa molecular distinta e comportamento cromatográfico diferenciado | sendo detectada por LC-MS e quantificada por UHPLC com detecção espectrométrica; NMR confirma a estereoquímica. Pode originar-se por introdução de flúor incompleta ou epimerização durante etapas de proteção e desproteção e exige controle por purificação adicional | cristalização ou cromatografia preparativa. O monitoramento em lote e a qualificação de limites de identificação e especificação são necessários para garantir conformidade e minimizar riscos de qualidade do ingrediente farmacêutico.
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![Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]](https://veeprho.com/wp-content/uploads/2022/07/Sofosbuvir-5-Desphosphate-3-O-5BS-Phosphate5D.png "Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]")
