Impureza 2-Hydroxy-N-[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylacetamide (CAS 2380769-62-8) é um subproduto quiral com três grupos hidroxila e um centro estereogênico 2R | cuja polaridade elevada altera significativamente o comportamento cromatográfico em HPLC e LC-MS. Sua presença pode indicar reações secundárias como hidroxilação ou migração de grupo durante etapas de síntese e purificação. Caracteriza-se por forte capacidade de formação de ligações de hidrogênio | solubilidade em meios polares e desafio na remoção por extração convencional. Recomenda-se monitoramento por métodos validados | quantificação por espectrometria de massa e NMR e avaliação de limites aceitáveis conforme guias de qualidade.
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