(3S | 4S)-Paroxol (CAS 100332-20-5) | também identificado como Paroxetine Impurity 5 | é uma impureza estereoespecífica associada à síntese de paroxetina. Apresenta configuração (3S | 4S) que exige métodos analíticos sensíveis para caracterização e quantificação | como HPLC acoplada a detector de massa | NMR e análise cromatográfica com coluna quiral para verificar pureza enantiomérica. A presença dessa impureza pode indicar rotas secundárias de reação ou condições de epimerização | sendo crítica para o controle de qualidade conforme requisitos regulatórios. Estratégias de redução incluem otimização de etapa sintética | purificação adicional e validação de limites de aceitação durante o desenvolvimento do processo.
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