5-Carboxyphthalide (CAS 4792-29-4) | também referido como 1-oxo-1 | 3-dihidro-2-benzofuran-5-carboxylic acid | Phthalide-5-carboxylic acid e variantes | é uma impureza carboxilada de interesse analítico em sínteses de compostos benzofurânicos; sua estrutura combina um anel lactona com um grupo carboxílico na posição 5 | conferindo caráter ácido e polar. A identificação e quantificação são realizadas por HPLC com detecção UV | LC-MS para confirmação de massa e RMN para elucidação estrutural. Considerada crítica para controle de qualidade | sua presença pode afetar rendimento | perfil de pureza e estabilidade do produto final | exigindo especificações | limites de aceitação e qualificação conforme diretrizes regulatórias aplicáveis.
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