O monômero N-nitrosopiperazina, também denominado mononitrosopiperazina, é uma impureza do tipo nitrosamina cíclica com fórmula molecular C4H9N3O e massa molecular de 115,13 g/mol. O CAS 5632-47-3 identifica este derivado N-nitroso da piperazina, classe associada a ativação metabólica, alquilação do DNA e preocupação genotóxica segundo os princípios da ICH M7. Sua formação pode ocorrer em condições nitrosantes durante a síntese ou por contaminação de intermediários contendo piperazina. A confirmação estrutural e a quantificação em nível traço geralmente exigem LC-MS/MS ou GC-MS, com separação cromatográfica ajustada a nitrosaminas voláteis e controle rigoroso de nitrosação artefatual.
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