A Cefdinir Lactone, CAS 946573-41-7, é uma substância relacionada definida do cefdinir, formada por lactonização intramolecular e rearranjo do esqueleto cefalosporínico contendo oximina. Com fórmula C14H13N5O5S2 e massa molecular de 395.41 g/mol, trata-se de um produto de degradação estruturalmente específico, e não de uma impureza de प्रक्रिया. Sua formação é mais provável sob condições ácidas, térmicas ou hidrolíticas, nas quais ocorrem transformações do heterociclo derivado do β-lactâmico. A quantificação normalmente requer LC-MS/MS ou LC-MS de alta resolução, frequentemente complementadas por HPLC-UV para separação e perfil de impurezas. É avaliada no contexto de controle de impurezas e caracterização de degradantes em cefalosporinas.
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