Informações adicionais sobre o Acyclovir EP Impurity Q
Fármaco de origem
Acyclovir
Nome IUPAC
2-Amino-9-(((2-hydroxyethoxy)methoxy)methyl)-1,9-dihydro-6H-purin-6-one compound with 2-amino-9-((2-(hydroxymethoxy)ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (1:1)
Sinônimos
N/A
Descrição
Acyclovir EP Impurity Q é uma impureza nucleosídica estruturalmente relacionada, com fórmula C18H26N10O8 e massa molecular 510.46. A sua composição indica um análogo de guanina altamente funcionalizado, compatível com um subproduto sintético oxidado ou sobreacilado, em vez de um simples resíduo de processo. Estas espécies podem formar-se durante sequências multietapa de proteção, glicosilação ou desproteção final empregadas na fabricação de aciclovir. Como impurezas de purina estreitamente relacionadas podem afetar a especificidade do ensaio e o perfil de impurezas, a caracterização geralmente exige LC em fase reversa acoplada a MS de alta resolução, frequentemente com suporte de fragmentação MS/MS e métodos ortogonais LC-UV para separação em nível de traço.
Referências
O’Brien, John J., and Deborah M. Campoli-Richards. “Acyclovir.†Drugs, vol. 37, no. 3, Mar. 1989, pp. 233–309, 10.2165/00003495-198937030-00002.
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