Adenosina EP Impurity G (Inosina | CAS 58-63-9) é uma impureza crítica frequentemente monitorada em controles de qualidade devido à sua ocorrência como derivado de degradação e isomerização; apresenta alta polaridade e boa solubilidade em água | resultando em tempos de retenção curtos em cromatografia líquida reversa e resposta consistente por detecção UV e ionização ESI em espectrometria de massas. A identificação robusta combina HPLC com comparação a padrão de referência | espectroscopia de massa e | quando necessário | RMN para confirmação estrutural. A validação de métodos analíticos deve incluir limites de detecção e quantificação | linearidade | precisão e recuperação | visando manter especificações de pureza e avaliar riscos de qualidade do lote.
Referências
Haskó, György, et al. “Immunomodulatory and Neuroprotective Effects of Inosine.â€Â Trends in Pharmacological Sciences, vol. 25, no. 3, Mar. 2004, pp. 152–57,  https://doi.org/10.1016/j.tips.2004.01.006.
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