Bromfenac N-β-D-Glucoside (CAS 212266-82-5) é uma impureza glicoconjugada do bromfenac caracterizada pela ligação N a um resíduo β-D-glicósido | gerando um incremento de massa correspondente a um monossacarídeo de aproximadamente 162 Da e aumento significativo da polaridade e solubilidade em meio aquoso. Esta espécie pode surgir por reações de glicossilação durante síntese ou armazenamento e exige investigação detalhada do perfil de impurezas por LC-MS/ESI e HPLC-UV com confirmação por RMN. Impacta parâmetros de estabilidade | biodisponibilidade e avaliação toxicológica | portanto controle analítico e limites conforme ICH são essenciais.
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